Format

Send to

Choose Destination
Comput Biol Chem. 2019 Feb;78:127-132. doi: 10.1016/j.compbiolchem.2018.11.021. Epub 2018 Nov 23.

Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach.

Author information

1
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, United States; Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), Mexico. Electronic address: gdeanda@inmegen.edu.mx.
2
Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), Mexico; Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México (UNAM), Mexico.
3
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, United States.
4
Inorganic Chemistry Department, Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico.
5
Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), Mexico; Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México (UNAM), Mexico. Electronic address: ehernandez@inmegen.gob.mx.

Abstract

Casiopeinas are a group of copper-based compounds designed to be used as less toxic, more efficient chemotherapeutic agents. In this study, we analyzed the in vitro effects of Casiopeina II-gly on the expression of canonical biological pathways. Using microarray data from HeLa cell lines treated with Casiopeina II-gly, we identified biological pathways that are perturbed after treatment. We present a novel approach integrating pathway analysis and network theory: The Pathway Crosstalk Network. We constructed a network with deregulated pathways, featuring links between those pathways that crosstalk with each other. We identified modules grouping deregulated pathways that are functionally related. Through this approach, we were able to identify three features of Casiopeina treatment: (a) Perturbation of signaling pathways, related to induction of apoptosis; (b) perturbation of metabolic pathways, and (c) activation of immune responses. These findings can be useful to drive new experimental exploration on their role in adverse effects and efficacy of Casiopeinas.

KEYWORDS:

Casiopeina; Copper; Genomics

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center