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Maturitas. 2019 Jan;119:21-24. doi: 10.1016/j.maturitas.2018.10.005. Epub 2018 Oct 22.

Botulinum toxin in women's health: An update.

Author information

1
The Royal Women's Hospital, 20 Flemington Road Parkville, Victoria 3052 Australia. Electronic address: annabelle.brennan@thewomens.org.au.
2
The Royal Women's Hospital, 20 Flemington Road Parkville, Victoria 3052 Australia; The University of Melbourne, Department of Obstetrics and Gynaecology, 7thFloor Royal Women's Hospital, 20 Flemington Road Parkville, Victoria 3052 Australia. Electronic address: hickeym@unimelb.edu.au.

Abstract

Botulinum toxin, from the bacteria Clostridium botulinum, acts by block the pre-synaptic release of acetylcholine at the neuromuscular junction, resulting in temporary muscle paralysis. There are several clinically available formulations, the most extensively studied being of onabotulinumtoxinA. This article outlines three of the common clinical applications of onabotulinumtoxinA relevant to women's health: the management of symptoms of overactive bladder, chronic migraine and facial lines. Its safety and efficacy have been well demonstrated but very few studies have directly compared treatments. Further research is needed directly comparing therapies to help guide treatment choices and predict success.

KEYWORDS:

Bladder dysfunction; Botox; Cosmetic; Facial lines; Migraine; Overactive bladder; Rhytides; Urinary incontinence; onabotulinumtoxinA

PMID:
30502747
DOI:
10.1016/j.maturitas.2018.10.005
[Indexed for MEDLINE]

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