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Chemosphere. 2019 Mar;218:652-661. doi: 10.1016/j.chemosphere.2018.11.136. Epub 2018 Nov 26.

Associations between endocrine disrupting chemicals and equine metabolic syndrome phenotypes.

Author information

1
Department of Veterinary Population Medicine, 225 Veterinary Medical Center, 1365 Gortner Avenue, St. Paul, MN, 55108, United States. Electronic address: durwa004@umn.edu.
2
Department of Veterinary Population Medicine, 225 Veterinary Medical Center, 1365 Gortner Avenue, St. Paul, MN, 55108, United States.
3
College of Veterinary Medicine, 1988 Fitch Avenue, St. Paul, 55108, United States.
4
BioDetection Systems b.v., Science Park 406, 1098 XH Amsterdam, the Netherlands.
5
College of Sciences, B2.13, Science Tower B, Massey University, Palmerston North, New Zealand.
6
Department of Veterinary and Biomedical Sciences, 301 Veterinary Science Building, 1971 Commonwealth Avenue, St. Paul, 55108, United States.

Abstract

Equine Metabolic Syndrome (EMS) is characterized by abnormalities in insulin regulation, increased adiposity and laminitis, and has several similarities to human metabolic syndrome. A large amount of environmental variability in the EMS phenotype is not explained by commonly measured factors (diet, exercise, and season), suggesting that other environmental factors play a role in EMS development. Endocrine disrupting chemicals (EDCs) are associated with metabolic syndrome and other endocrine abnormalities in humans. This led us to hypothesize that EDCs are detectable in horse plasma and play a role in the pathophysiology of EMS. EDCs acting through the aryl hydrocarbon and estrogen receptors, were measured in plasma of 301 horses from 32 farms. The median (range) TEQ (2,3,7,8-TCDD equivalent) and EEQ (17β-estradiol equivalent) were 19.29 pg/g (0.59-536.36) and 10.50 pg/ml (4.35-15000.00), respectively. TEQ was negatively associated with plasma fat extracted and batch analyzed. EEQ was positively associated with pregnancy and batch analyzed, and negatively associated with being male and superfund score ≤100 miles of the farm. Of particular interest, serum glucose and insulin, glucose and insulin post oral sugar challenge, and leptin concentrations were associated with EEQ, and serum triglyceride concentration was associated with TEQ. Overall, we demonstrated that EDCs are present in the plasma of horses and may explain some of the environmental variability in measured EMS phenotypes. This is the first example of EDCs being associated with clinical disease phenotype components in domestic animals.

KEYWORDS:

Endocrine disrupting chemicals; Environment; Equine; Metabolic syndrome

PMID:
30502704
PMCID:
PMC6347404
[Available on 2020-03-01]
DOI:
10.1016/j.chemosphere.2018.11.136
[Indexed for MEDLINE]

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