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J Pediatr Adolesc Gynecol. 2019 Apr;32(2):117-121. doi: 10.1016/j.jpag.2018.11.008. Epub 2018 Nov 28.

Ovarian Function in Adolescents Conceived Using Assisted Reproductive Technologies.

Author information

1
Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile. Electronic address: pmerino@med.uchile.cl.
2
Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile; Cytogenetics Laboratory, Hospital Clínico San Borja Arriarán, Santiago, Chile.
3
Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile.
4
Department of Obstetrics and Gynecology, Clinica Las Condes, Santiago, Chile.

Abstract

STUDY OBJECTIVE:

To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).

DESIGN:

Multicenter study of ovarian function in AcART because of male or tubal infertility.

SETTING:

University Hospital.

PARTICIPANTS:

We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. The participants were born at term (≥37 weeks of gestation) with normal birth weights (≥2500 g) from singleton pregnancies.

INTERVENTIONS:

None.

MAIN OUTCOME MEASURES:

Differences in ovulation, reproductive hormones, and ovarian morphology.

RESULTS:

AcART had an older age of menarche than that of AcSP, even after adjusting for maternal age at menarche, gestational age, and birth weight (P = .027). AcART had lower incidence of ovulation (P = .021) and higher luteinizing hormone serum levels (P = .01) than those of AcSP. The incidence of oligomenorrhea and the cycle length were similar between AcART and AcSP. AcART had levels of anti-Müllerian hormone, inhibin B, follicle-stimulating hormone, estradiol, and androgens similar to those of AcSP. The ovarian morphology, ovarian volume, and follicle counts were similar in both groups.

CONCLUSION:

AcART had later menarche, lower ovulation rates, and higher luteinizing hormone levels than those of AcSP. Future studies should investigate whether these findings are indicative of a risk of ovarian dysfunction later in life for AcART.

KEYWORDS:

Age of menarche; Anti-Müllerian hormone; Assisted reproductive technology; IVF offspring; Inhibin B; Ovulation rate

PMID:
30502496
DOI:
10.1016/j.jpag.2018.11.008
[Indexed for MEDLINE]

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