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Nanomedicine. 2019 Feb;16:10-19. doi: 10.1016/j.nano.2018.11.007. Epub 2018 Nov 28.

Magneto-nanosensor smartphone platform for the detection of HIV and leukocytosis at point-of-care.

Author information

1
Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: elaineng@stanford.edu.
2
Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
3
Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
4
Cloud DX Inc., Kitchener, Ontario, Canada.
5
Department of Electrical Engineering, Stanford University, Stanford, CA, USA; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.

Abstract

The advent of personalized medicine has brought an increased interest in personal health among general consumers. As a result, there is a great need for user-centric point-of-care (POC) health devices. Such devices are equally pertinent in developing countries or resource-limited settings for performing diagnostic tests. However, current POC tests for diseases such as human immunodeficiency virus (HIV) or leukocytosis do not provide adequate levels of sensitivity or do not exist at all. Here, we extend our mobile magneto-nanosensor platform to point-of-care HIV and leukocytosis detection. The platform can be multiplexed, and the circuitry enables portability and sensitivity in the POC setting. A smartphone application simplifies operation and provides guidance to facilitate self-testing. Commercially available POC test kits typically provide only qualitative or semi-quantitative results of a single analyte. The magneto-nanosensor platform can provide users with pleasant user-experience while demonstrating robust sensitive and specific multiplexed quantification and detection of common diseases.

KEYWORDS:

HIV; Leukocytosis; Magnetic nanoparticles; Magneto-nanosensor array; Multiplexed immunoassays; Point-of-care

PMID:
30502420
DOI:
10.1016/j.nano.2018.11.007
[Indexed for MEDLINE]

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