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Infect Control Hosp Epidemiol. 2019 Jan;40(1):72-78. doi: 10.1017/ice.2018.276. Epub 2018 Dec 3.

The clinical impact of a urinary tract infection management bundle in a tertiary-care teaching hospital.

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1Department of Pharmacy Services,Horizon Health Network,Moncton, New Brunswick,Canada.
2Family Practice,Fraser Health,New Westminster, British Columbia,Canada.
3Dalhousie University Department of Medicine,Halifax, Nova Scotia,Canada.
4Department of Laboratory Medicine,Horizon Health Network,Moncton, New Brunswick,Canada.
5Département de mathématiques et statistique,Université de Moncton,Moncton, New Brunswick,Canada (retired).
6Department of Internal Medicine,Horizon Health Network,Moncton, New Brunswick,Canada.



The aim of this study was to assess the impact of a urinary tract infection (UTI) management bundle to reduce the treatment of asymptomatic bacteriuria (AB) and to improve the management of symptomatic UTIs.


Before-and-after intervention study.SettingsTertiary-care hospital.PatientsConsecutive sample of inpatients with positive single or mixed-predominant urine cultures collected and reported while admitted to the hospital.


The UTI management bundle consisted of nursing and prescriber education, modification of the reporting of positive urine cultures, and pharmacists' prospective audit and feedback. A retrospective chart review of consecutive inpatients with positive urinary cultures was performed before and after implementation of the management bundle.


Prior to the implementation of the management bundle, 276 patients were eligible criteria for chart review. Of these 276 patients, 165 (59·8%) were found to have AB; of these 165 patients with AB, 111 (67·3%) were treated with antimicrobials. Moreover, 268 patients met eligibility criteria for postintervention review. Of these 268, 133 patients (49·6%) were found to have AB; of these 133 with AB, 22 (16·5%) were treated with antimicrobials. Thus, a 75·5% reduction of AB treatment was achieved. Educational components of the bundle resulted in a substantial decrease in nonphysician-directed urine sample submission. Adherence to a UTI management algorithm improved substantially in the intervention period, with a notable decrease in fluoroquinolone prescription for empiric UTI treatment.


A UTI management bundle resulted in a dramatic improvement in the management of urinary tract infection, particularly a reduction in the treatment of AB and improved management of symptomatic UTI.


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