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Curr Med Chem. 2018 Dec 3. doi: 10.2174/0929867326666181203130402. [Epub ahead of print]

Oxazole-based compounds as anticancer agents.

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Dipartimento di Scienze del Farmaco, University of Catania, V.le Doria 6, 95125 Catania. Italy.
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, University of Messina, Via S.S. Annunziata, 98168 Messina. Italy.
Dipartimento di Ingegneria, University of Messina, Contrada Di Dio, 98166 Messina. Italy.
Dipartimento di Chimica, University of Pavia, Via Taramelli 12, 27100 Pavia. Italy.


Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various type of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the new discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.


Anticancer activity; Isoxazole; Oxazole; Oxazolidine; Oxazoline; Synthesis.

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