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Tissue Eng Part C Methods. 2019 Jan;25(1):1-11. doi: 10.1089/ten.TEC.2018.0260.

Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats.

Author information

1
1 Inserm, UMR 1238, PHY-OS, Laboratory of Bone Sarcomas and Remodelling of Calcified Tissues, Faculty of Medicine, University of Nantes, Nantes, France.
2
2 Faculty of Dental Surgery, CHU Nantes, Nantes, France.
3
3 Mimetis Biomaterials, Barcelona, Spain.
4
4 Department of AnatomoPathology, CHU Tours, Tours, France.
5
5 Centre for Investigation on Pre-Clinical Research, Veterinary School of Nantes, ONIRIS, Nantes, France.
6
6 Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Polit├Ęcnica de Catalunya, Barcelona, Spain.

Abstract

This work reports a new bone substitute made of precipitated apatite crystals that resemble in composition and crystallinity to the mineral phase of bone. The bone regeneration capacity of this synthetic biomimetic calcium phosphate (SBCP) was studied by using an original model of vertical bone regeneration with cups on the calvaria of rats. After 4 weeks, a significantly higher bone growth was found with SBCP compared with deproteinized bovine bone matrix and empty controls. This rapid vertical bone regeneration indicated that this new biomaterial is particularly interesting for filling bone defects in oral surgery.

KEYWORDS:

calvaria; cups; deproteinized bovine bone matrix; hydroxyapatite; rats; synthetic biomimetic calcium phosphate; vertical bone regeneration

PMID:
30501579
DOI:
10.1089/ten.TEC.2018.0260

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