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Ann Otol Rhinol Laryngol. 2018 Dec 2:3489418815188. doi: 10.1177/0003489418815188. [Epub ahead of print]

Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty.

Author information

1
1 Albert Einstein College of Medicine, Bronx, New York, USA.
2
2 Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, New York, USA.
3
3 Department of Head and Neck Surgery, University of California, Los Angeles, California, USA.

Abstract

OBJECTIVES::

To provide an up-to-date review of honey's effectiveness and potential applications in otorhinolaryngology.

METHODS::

A literature search of the online databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials was conducted.

RESULTS::

Sixty-three studies were identified within head and neck surgery (n = 23, 36%); pediatric otolaryngology (n = 18, 29%); rhinology, sinus, and skull base surgery (n = 11, 17%); otology (n = 6, 10%), facial plastic and reconstructive surgery (n = 3, 5%); and laryngology (n = 2, 3%). Studies included 6 meta-analyses, 44 randomized control trials, 5 case reports, and 8 animal models or in vitro studies. Of 55 clinical studies, 50 reported Level 1 evidence (prospective randomized control trials), and 5 reported Level 4 evidence (case series). The evidence level by subspecialty was: head and neck surgery (Level 1 n = 23), pediatrics (Level 1 n = 18), rhinology (Level 1 n = 7, level 4 n = 1), otology (Level 1 n = 1, Level 4 n = 3), facial plastics and reconstructive surgery (Level 4 n = 1), and laryngology (Level 1 n = 2).

CONCLUSIONS::

Honey can be used for a variety of otolaryngology conditions. The highest quality meta-analyses support oral honey for prevention and treatment of oral mucositis in cancer patients, cough associated with upper respiratory infection in children, and pain control after tonsillectomy. Further research will likely justify broader applications.

KEYWORDS:

complementary therapies; evidence-based medicine; honey; otolaryngology; treatment outcomes

PMID:
30501505
DOI:
10.1177/0003489418815188

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