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Angew Chem Int Ed Engl. 2018 Nov 30. doi: 10.1002/anie.201811951. [Epub ahead of print]

Exploring the Fundamental Structures of Life: Non-targeted, Chemical Analysis of Single Cells and Subcellular Structures.

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Department of Chemistry and the Beckman Institute for Advanced Science and Technology, 405 N. Mathews Avenue, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States, UNITED STATES.
Department of Chemistry, 1420 Circle Drive, University of Tennessee, Knoxville, Tennessee 37996, United States, UNITED STATES.
University of Illinois, Department of Chemistry, 600 S. Mathews Ave. 63-5, 61801-5004, Urbana, UNITED STATES.


Cells are a basic functional and structural unit of living organisms. Both unicellular communities and multicellular species produce an astonishing chemical diversity, enabling a wide range of divergent functions, yet each cell shares numerous aspects that are common to all living organisms. While there are many approaches for studying this chemical diversity, only a few are non-targeted and capable of analyzing hundreds of different chemicals at cellular resolution. Here, we review the non-targeted approaches used to perform comprehensive chemical analyses, provide chemical imaging information, or obtain high-throughput single cell profiling data. Single cell measurement capabilities are rapidly increasing in terms of throughput, limits of detection, and completeness of the chemical analyses; these improvements enable their application to understand ever more complex physiological phenomena such as learning, memory, and behavior.


Analytical methods; Bioanalysis; Mass Spectrometry; Single Cell Analysis; imaging


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