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Cell. 2018 Nov 29;175(6):1461-1463. doi: 10.1016/j.cell.2018.11.016.

Revitalizing Aging Skin through Diet.

Author information

1
Departments of Dermatology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: millars@pennmedicine.upenn.edu.

Abstract

Mechanisms underlying aging of the skin dermis are poorly understood. Now, two studies (Marsh et al., 2018; Salzer et al., 2018) describe complementary approaches to this question: Salzer et al. show that aging dermal fibroblasts lose defined identity in a diet-influenced fashion, and Marsh et al. reveal that fibroblast loss over time is compensated by membrane expansion rather than proliferation, resulting in decreased cellular density.

PMID:
30500532
DOI:
10.1016/j.cell.2018.11.016

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