Format

Send to

Choose Destination
Psychiatry Res Neuroimaging. 2018 Nov 22;283:24-33. doi: 10.1016/j.pscychresns.2018.11.009. [Epub ahead of print]

Cerebellar structural and functional abnormalities in first-episode and drug-naive patients with schizophrenia: A meta-analysis.

Author information

1
Department of Psychiatry, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China.
2
Department of Radiology, Tianjin Medical University General Hospital. Tianjin 300000, China.
3
Department of Psychiatry, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China. Electronic address: guowenbin76@csu.edu.cn.

Abstract

Schizophrenia (SZ) is a mental disorder that involves cerebral and cerebellar abnormalities. The cerebellum plays an indispensable role in the pathophysiology of SZ. However, individual studies pertaining to the structural and resting-state functional cerebellar abnormalities in patients with SZ have been inconsistent. To make a relatively robust conclusion with little interference, such as different disease episode times and antipsychotic treatment, we conducted this meta-analysis as a first attempt to comprehensively analyze and combine studies of voxel-based morphometry (VBM), amplitude of low-frequency fluctuation (ALFF), and functional connectivity strength (FCS) in first-episode and drug-naive SZ patients, employing the Seed-based d Mapping (SDM) method. Thirteen VBM studies, eight ALFF studies, and three FCS studies involving 783 patients and 704 matched healthy controls were included. Our results showed the presence of structural and functional abnormalities within the cerebellar regions, including most superior/anterior cerebellum (lobule III-V or VI) and posterior/inferior cerebellum (lobule VIII) related to motor function, and posterior cerebellum (lobule VIIa, Crus I, and II) associated with cognition and emotion, and such anomalies might be related to illness duration and clinical symptom severity.

KEYWORDS:

Amplitude of low-frequency fluctuation (ALFF); Functional connectivity strength (FCS); Magnetic resonance imaging (MRI); Voxel-based morphometry (VBM)

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center