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Neurochem Int. 2019 Jan;122:144-148. doi: 10.1016/j.neuint.2018.11.019. Epub 2018 Nov 28.

Protective potentials of far-infrared ray against neuropsychotoxic conditions.

Author information

1
Neuropsychopharmacology and Toxicology Program, BK21 PLUS Project, College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea.
2
College of Forest and Environmental Sciences, Kangwon National University, Chunchon, 24341, Republic of Korea.
3
Department of Internal Medicine, Medical School, Kangwon National University, Chunchon, 24341, Republic of Korea.
4
Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea.
5
Department of Pharmacology, School of Pharmacy, Sungkyunkwan University Suwon 16419, Republic of Korea.
6
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea.
7
Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, Aichi, 470-1192, Japan.
8
Section of Prophylactic Pharmacology, Room 402, Venture Business Laboratory, Kanazawa University, Kanazawa, Ishikawa, 920-1192, Japan.
9
Molecular Neuropsychiatry Section, NIH Bayview Research Centre 251, Bayview Boulevard, Baltimore, MD, 21224, USA.
10
Neuropsychopharmacology and Toxicology Program, BK21 PLUS Project, College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea. Electronic address: kimhc@kangwon.ac.kr.

Abstract

Compelling evidence suggests that far-infrared ray (FIR) possesses beneficial effects on emotional disorders. However, the underlying mechanism conveyed by FIR remains unclear. Recently, we demonstrated that exposure to FIR induces antioxidant potentials via up-regulation of glutathione peroxidase (GPx)-1 gene. The antioxidant potentials might be important for the modulation on the neuropsychotoxic conditions. Exposure to FIR protects from methamphetamine (MA)-induced memory impairments via phosphorylation of ERK 1/2 signaling by positive modulation of protein kinase C δ (PKCδ), M1 muscarinic acetylcholine receptor (M1 mAChR), and nuclear factor E2-related factor 2 (Nrf2) transcription factor. In addition, exposure to FIR positively modulates MA-induced behavioral sensitization via attenuating mitochondrial dysfunction by down-regulation of dopamine D1 receptor. In this mini-review, we have discussed with the protective potentials mediated by FIR against MA-induced psychotoxic burdens.

KEYWORDS:

Behavioral sensitization; Far-infrared ray; Glutathione peroxidase-1 gene; Memory impairments; Methamphetamine

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