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Int J Neurosci. 2018 Nov 30:1-13. doi: 10.1080/00207454.2018.1554657. [Epub ahead of print]

Measuring abnormal intrinsic brain activities in patients with retinal detachment using amplitude of low-frequency fluctuation: a resting-state fMRI study.

Author information

1
a Department of Ophthalmology , The First Affiliated Hospital of Nanchang University , Nanchang 330006 , Jiangxi , China.
2
b Department of Radiology , The First Affiliated Hospital of Nanchang University , Nanchang 330006 , Jiangxi , China.

Abstract

OBJECTIVE:

The targets of this study was to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance.

METHODS:

20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning. We applied the ALFF method to detect the spontaneous brain activity. Receiver operating characteristic (ROC) curve was applied to distinguish RD Patients from HCs.

RESULTS:

RD patients showed decreased ALFF values in the right occipital lobe and right medial frontal gyrus and increased ALFF values in the right frontal superior orbital and left inferior temporal gyrus when compared with HCs. In RD patients, we did not find any relationship between the mean ALFF values and the clinical behavioral performances.

CONCLUSION:

The RD patients exhibited abnormal spontaneous brain activity in vision and vision related brain regions, which might explore potential pathological mechanism of acute vision loss in RD patients.

KEYWORDS:

ALFF; Functional magnetic resonance imaging; Resting state; Retinal detachment

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