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Diabet Med. 2018 Nov 30. doi: 10.1111/dme.13872. [Epub ahead of print]

The association between vascular complications during pregnancy in women with Type 1 diabetes and congenital malformations.

Author information

1
Departments of Medicine, University of Calgary, Calgary Alberta, Canada.
2
Obstetrics and Gynecology, University of Calgary, Calgary Alberta, Canada.
3
Community Health Sciences, University of Calgary, Calgary Alberta, Canada.
4
Pediatrics, Cumming School of Medicine, University of Calgary, Calgary Alberta, Canada.
5
Alberta Perinatal Health Program, Alberta Health Services, University of Calgary, Calgary Alberta, Canada.
6
Libin Cardiovascular Institute, University of Calgary, Calgary Alberta, Canada.
7
O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary Alberta, Canada.

Abstract

AIMS:

To assess the association between vascular complications of diabetes and the risk of congenital malformations in pregnant women with Type 1 diabetes.

METHODS:

We conducted an observational retrospective cohort study in women with Type 1 diabetes who received care consecutively from three tertiary care diabetes-in-pregnancy clinics in Calgary, Alberta, Canada. Multivariable logistic regression was used to assess the association between vascular complications (retinopathy, nephropathy and pre-existing hypertension) and congenital malformations in offspring of women with Type 1 diabetes.

RESULTS:

Of 232 women with Type 1diabetes, 49 (21%) had at least one vascular complication and there were 52 babies with congenital malformations. Maternal age (31.8 ± 5.0 vs. 29.4 ± 4.7 years, P < 0.01), diabetes duration (20.9 ± 6.7 vs. 11.2 ± 7.4 years, P < 0.01) and pre-eclampsia rate (12.5% vs. 1.3%, P < 0.01) were higher in mothers with vascular complications than in those without. Multivariable analyses showed that vascular complications were not associated with an increased risk of congenital malformations (odds ratio 1.16, 95% confidence interval 0.46 to 2.88).

CONCLUSIONS:

Vascular complications are common, occurring in one-fifth of pregnant women with Type 1 diabetes, and in this study do not appear to be associated with an increased risk of congenital malformations in children. This article is protected by copyright. All rights reserved.

PMID:
30499197
DOI:
10.1111/dme.13872

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