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Cancer Discov. 2019 Jan;9(1):OF2. doi: 10.1158/2159-8290.CD-NB2018-157. Epub 2018 Nov 29.

Mixed Reviews for A2AR Inhibitor in NSCLC.

[No authors listed]


Findings of a phase I/II trial of the adenosine 2A receptor blocker NIR178 combined with the PD-1 inhibitor spartalizumab in advanced non-small cell lung cancer suggest that the drugs are safe. Two of 25 patients showed complete or partial responses, and 13 had stable disease.

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