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PLoS One. 2018 Nov 29;13(11):e0207146. doi: 10.1371/journal.pone.0207146. eCollection 2018.

Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study.

Author information

1
Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2
Department of Psychology, Yonsei University, Seoul, Korea.
3
Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
4
Department of Medical Education, Yonsei University College of Medicine, Seoul, Korea.
5
Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

PURPOSE:

To characterize resting-state brain activation patterns and investigate altered areas for cognitive decline in HIV patients.

METHODS:

Twelve male HIV patients with intact cognition (HIV-IC), 10 with HIV-associated neurocognitive disorder (HAND), and 11 male healthy controls (HC) underwent resting-state functional MRI (rsfMRI). Three rsfMRI values, regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between groups. Correlation analyses were performed between rsfMRI values and neuropsychological tests.

RESULTS:

rsfMRI analyses revealed decreased rsfMRI values in the frontal areas, and increases in the posterior brain regions for both HIV-IC and HAND compared to HC. When directly compared to HIV-IC, HAND showed lower fALFF in the orbitofrontal cortex and higher ReHo in the primary sensorimotor area. Additionally, decreased orbitofrontal fALFF, increased sensorimotor ReHo, and a larger difference between the two values were highly correlated with decreased verbal memory and executive function in HIV patients.

CONCLUSIONS:

Regardless of cognitive status, altered local intrinsic activities were found in HIV patients. The orbitofrontal cortex and primary sensorimotor area were more disrupted in HAND relative to HIV-IC and correlated with behavioral performance, suggesting these areas are relevant to cognitive impairment in HIV patients.

PMID:
30496203
DOI:
10.1371/journal.pone.0207146
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Conflict of interest statement

The authors have declared that no competing interests exist.

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