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Food Chem Toxicol. 1988 Jun;26(6):541-65.

Methylxanthines: toxicity to humans. 1. Theophylline.

Author information

1
Food Research Division, Bureau of Chemical Safety, Health Protection Branch, Ottawa, Ontario, Canada.

Abstract

While there are several comprehensive reviews on the toxic effects of theophylline, caffeine and theobromine in animals, data on the toxicity of these methylxanthines in humans have not been extensively reviewed in one document. This question will be addressed in a series of three papers. This paper provides an overview of the human toxicity of theophylline. Only pertinent and recent information on theophylline toxicity is summarized. In addition, some information regarding the use and benefits of theophylline, the mechanism of its effects and factors that affect variability in its clearance and half-life is also provided. Some problems in the analytical methodology of theophylline, problems that may be responsible for the controversy in the reported dose-response effects, are critically reviewed.

PMID:
3049277
DOI:
10.1016/0278-6915(88)90007-5
[Indexed for MEDLINE]

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