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Eur J Cancer Prev. 2019 Jul;28(4):294-303. doi: 10.1097/CEJ.0000000000000483.

Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors.

Author information

1
University Hospital of Guadalajara (SESCAM), Guadalajara.
2
Teaching Unit of Preventive and Public Health, Institute of Health Sciences, Talavera de la Reina.
3
Cancer and Environmental Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III.
4
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP).
5
Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer (DKFZ), Research Center, Heidelberg, Germany.
6
Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute.
7
Spanish Network for Research in Infectious Diseases.
8
Gastroenterology Department, Hospital del Mar.
9
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona.
10
Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL.
11
Research Group in Gene-Environment Interactions and Health, University of León, Leon.
12
Public Health Division of Gipuzkoa, BioDonostia Research Institute.
13
Navarra Institute for Health Research (IdiSNA), Pamplona.
14
Oncology Institute, University of Oviedo, Oviedo.
15
University of Cantabria -Marqués de Valdecilla Research Institute (IDIVAL), Santander.
16
Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Valencia.
17
Natural Resources, Health and Environment Research Center, University of Huelva, Huelva (RENSMA).
18
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca.
19
Department of Health and Social Sciences, University of Murcia, Murcia.
20
Granada Health Research Institute (ibs.GRANADA).
21
Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.
22
Department of Pathology, Donostia University Hospital, Donostia.
23
Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat.
24
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL).
25
IMIM (Hospital del Mar Medical Research Institute).
26
Pompeu Fabra University, Barcelona.
27
Department of Health, Epidemiology Section, Public Health Division, Madrid.

Abstract

Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. The aim of this study was to describe the association of adult and childhood sociodemographic factors with the seroprevalence of H. pylori, and with CagA and VacA antigen-specific seropositivity among H. pylori-seropositive individuals in the Spanish adult population. Serum antibody reactivity to H. pylori proteins was evaluated using multiplex serology in 2555 population-based controls enrolled in the MCC-Spain study, a multicase-control study recruiting participants from 2008 to 2013 in different areas of Spain. H. pylori seroprevalence was defined as seropositivity against at least four bacterial proteins. Information on sociodemographics, lifestyles, and environmental exposures was collected through personal interviews. Prevalence ratios and 95% confidence intervals were estimated using Poisson regression models to assess the association of lifetime sociodemographic factors with H. pylori seroprevalence and with seropositivity for CagA and VacA. H. pylori seroprevalence was 87.2%. Seropositivity was statistically significantly higher in men, increased with age, BMI, and number of siblings, and decreased with education and socioeconomic family level at birth. Among H. pylori-seropositive individuals, seropositivity was 53.3% for CagA, 61.4% for VacA, and 38.8% for both CagA and VacA. Ever smokers had lower seroprevalence for CagA and VacA than never smokers. H. pylori seroprevalence among this Spanish adult population was high and one third of the population was seropositive for two well-known markers of gastric cancer risk: CagA and VacA. Sex, age, education, and BMI were associated with H. pylori seroprevalence.

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