Format

Send to

Choose Destination
J Clin Res Pediatr Endocrinol. 2018 Nov 29. doi: 10.4274/jcrpe.0210. [Epub ahead of print]

Management of thyrotoxicosis in children and adolescence: a Turkish multi-center experience.

Author information

1
Fırat Üniversitesi Tıp Fakültesi, Çocuk Endokrinoloji Bilim Dalı, Elazığ, Turkey.
2
Dr. Sami Ulus Kadın Doğum Çocuk Sağ. ve Hast. E.A.H., Çocuk Endokrinoloji Kliniği, Ankara, Turkey.
3
Kanuni Sultan Süleyman E.A.H., Çocuk Endokrinoloji Kliniği, Istanbul, Turkey.
4
Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Samsun, Turkey.
5
Istanbul Üniversitesi, Istanbul Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Istanbul, Turkey.
6
Düzce Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Düzce, Turkey.
7
Adana Şehir Hastanesi, Çocuk Endokrinoloji Kliniği, Adana, Turkey.
8
Dicle Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Diyarbakır.
9
Göztepe E.A.H., Çocuk Endokrinolojisi Kliniği, Istanbul, Turkey.
10
Istanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Istanbul, Turkey.
11
Erzurum Bölge E.A.H., Çocuk Endokrinolojisi Kliniği, Erzurum, Turkey.
12
Çukurova Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Adana, Turkey.
13
Derince E.A.H., Çocuk Endokrinolojisi Kliniği, Kocaeli, Turkey.
14
Gazi Üniversitesi Tıp Fakültesi, Çocuk Endokrinoloji Bilim Dalı, Ankara, Turkey.
15
Konya E.A.H., Çocuk Endokrinoloji Kliniği, Konya, Turkey.
16
Zeynep Kamil Kadın ve Çocuk Hastalıkları E.A.H., Çocuk Endokrinoloji Kliniği, Istanbul, Turkey.
17
Gülhane E.A.H., Çocuk Endokrinoloji Kliniği, Ankara, Turkey.
18
Çorlu Devlet Hastanesi, Çocuk Endokrinolojisi Kliniği, Tekirdağ, Turkey.
19
Bağcılar E.A.H., Çocuk Endokrinoloji Kliniği, Istanbul, Turkey.
20
Diyarbakır Çocuk Hastanesi, Çocuk Endokrinolojisi Kliniği, Diyarbakır, Turkey.
21
Gaziantep Üniversitesi Tıp Fakültesi, Çocuk Endokrinolojisi Bilim Dalı, Gaziantep, Turkey.
22
Gaziosmanpaşa Taksim E.A.H., Çocuk Endokrinoloji Kliniği, Istanbul, Turkey.

Abstract

OBJECTIVE:

To determine demographic and biochemical features of childhood and juvenile thyrotoxicosis and determine the treatment outcomes in them.

METHODS:

We reviewed records of 503 children from in 12 different cities of Turkey who were diagnosed with thyrotoxicosis between 2007 to 2017.

RESULTS:

In all, 375 (74.6%) patients had been diagnosed with Graves' disease (GD) and 75 (14.9%) had hashitoxicosis, and 53 (10.5%) had been diagnosed with uncommon causes of thyrotoxicosis. Commonest presenting features in children with GD or hashitoxicosis were tachycardia and/or palpitation, weight loss and excessive sweating. The cumulative remission rate was 17.6% in 370 patients with GD who received ATDs for initial treatment, and were treated for a median of 22.8 months (range 0.3 - 127 months). No variables predictive of the achievement of remission were identified. Twenty-seven patients with GD received second-line treatment for poor disease control and adverse events associated with antithyroid drugs. Total thyroidectomy was reported in 17 patients with no recurrence of thyrotoxicosis and all became hypothyroid. Ten patients received radioiodine; six became hypothyroid, 1 remained hyperthyroid and started taking antithyroid drug again; 1 achieved remission and 2 unknown progresses due to lost up follow up.

CONCLUSION:

This study demonstrated that using anti-thyroid drugs with the hope that the patients will enter a remission over time is generally accepted first-line approach in Turkish children and adolescents with GD, however, this approach achieved low remission rate which was consistent with previous studies.

PMID:
30488822
DOI:
10.4274/jcrpe.0210
Free full text

Supplemental Content

Full text links

Icon for Galenos Yayinevi
Loading ...
Support Center