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Endocr Metab Immune Disord Drug Targets. 2018 Nov 28. doi: 10.2174/1871530319666181129103056. [Epub ahead of print]

Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences.

Author information

1
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran. Iran.
2
Iranian Center of Neurological Research, Sina Hospital, Tehran University of Medical Sciences, Tehran. Iran.

Abstract

OBJECTIVE:

Neuroinflammatory disease is a general term used to denote the progressive loss of neuronal function or structure. Many neuroinflammatory diseases, including Alzheimer's, Parkinson's, and multiple sclerosis (MS), occur due to neuroinflammation. Neuroinflammation increases nuclear factor-κB (NF-κB) levels, cyclooxygenase-2 enzymes and inducible nitric oxide synthase, resulting in the release of inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). It could also lead to cellular deterioration, and symptoms of neuroinflammatory diseases. Recent studies have suggested that curcumin (the active ingredient in turmeric) may could alleviate the process of Neuroinflammatory disease. Thus, the present mini-review was conducted to summarize studies regarding cellular and molecular targets of curcumin relevant to neuroinflammatory disorders.

METHODS:

A literature search strategy was conducted for all English-language literature.Studies that assessed the various propertieses of curcuminoids in respect of neuroinflammatory disorders were entered in this review.

RESULTS:

the studies have suggested that Curcuminoids has significant anti- neuroinflammatory, antioxidant and neuroprotective properties that could attenuate the development and symptom of neuroinflammatory disorders. Curcumin can alleviate neurodegeneration and neuroinflammation through multiple mechanisms, including by reducing inflammatory mediators (such as TNF-α, IL-1β, nitric oxide and NF-κB gene expression), and affect mitochondrial dynamics and even epigenetic changes.

CONCLUSION:

it is a promising subject of study in the prevention and management of neuroinflammatory disease. However, controlled, randomized clinical trials are needed to fully evaluate its clinical potential.

KEYWORDS:

Multiple sclerosis; Curcumin; Nanocurcumin ; Neuroinflammatory Disorders; Alzheimer’s disease; Parkinson’s disease

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