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Pediatr Dermatol. 2018 Nov 28. doi: 10.1111/pde.13732. [Epub ahead of print]

Aluminum granuloma in a child secondary to DTaP-IPV vaccination: A case report.

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Department of Dermatology, Oregon Health & Science University, Portland, Oregon.
Department of Pathology, Oregon Health & Science University, Portland, Oregon.
Division of Pediatric Surgery, Oregon Health & Science University, Portland, Oregon.


Reports detailing the acute formation of aluminum granulomas, which can cause persistent, intensely pruritic nodules secondary to the administration of aluminum-containing vaccines, are infrequently described in medical literature. To our knowledge, this is the first report describing the development of an aluminum granuloma causing a persistent, pruritic nodule at the injection site following the administration of the DTaP-IPV vaccine. We present the case of a 6-year-old girl who developed a severely pruritic subcutaneous nodule on her anterior right thigh at the injection site three weeks after the administration of the aluminum-containing DTaP-IPV (Kinrix) vaccine. The nodule was eventually excised 14 months after its initial appearance, after which her symptoms resolved. Histologic inspection demonstrated a dense, deep dermal and subcutaneous nodular mixed infiltrate of lymphocytes, histiocytes, and eosinophils, with germinal center formation. The bluish, amphophilic granular cytoplasm found in most of the histiocytes is a characteristic feature of "aluminum granulomas." This adverse reaction should be considered in any patient presenting with similar findings in the weeks following a DTaP-IPV vaccination or other aluminum-containing vaccines. Furthermore, the self-limiting tendency of these nodules should not preclude affected patients from any future vaccinations, though vaccines without aluminum should be preferentially selected when possible.


aluminum granuloma; dermatopathology; pediatric dermatology; subcutaneous nodule; vaccine site reactions; vaccines


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