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J Neurochem. 2019 May;149(3):317-330. doi: 10.1111/jnc.14637. Epub 2019 Jan 15.

Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review.

Author information

1
Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
3
Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
4
Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
5
Cochrane Schizophrenia Group, Institute of Mental Health, University of Nottingham, Nottingham, UK.
6
Department of Orthopedics and Neurosurgery, Rothman Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
7
Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
8
Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
9
Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
10
Department of Surgery and Spine Program, University of Toronto, Toronto, Ontario, Canada.
11
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
12
Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
13
Brain and Spinal Injuries Research Center (BASIR), Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

It remains unclear whether biomarkers in the serum or CSF can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic or diagnostic value of serum and CSF biomarkers in assessing the severity of SCI and the outcome of patients. Two independent reviewers summarized the human studies retrieved from the electronic databases of Medline, Embase, Scopus and ISI Web of Science until April 2018. Seventeen studies were included (1065 patients aged 16-94 years old). Although the findings of the included studies suggest that inflammatory and structural proteins may be useful in assessing the severity of SCI and prediction of neurological outcome, the level of evidence is generally low. Given limitations to the available evidence, further investigation in this field is required using large prospective data sets with rigorous analysis of sensitivity, specificity and prediction.

KEYWORDS:

biomarkers; prognostics value; spinal cord injuries

PMID:
30488446
DOI:
10.1111/jnc.14637

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