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Breast Cancer Res. 2018 Nov 28;20(1):146. doi: 10.1186/s13058-018-1077-9.

Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221).

Author information

1
University at Buffalo, Buffalo, NY, USA.
2
Roswell Park Cancer Institute, Buffalo, NY, USA.
3
Boston University, Boston, MA, USA.
4
The Ohio State University, Columbus, OH, USA.
5
Columbia University, New York, NY, USA.
6
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
7
Cleveland Clinic, Cleveland, OH, USA.
8
Baystate Medical Center, Springfield, MA, USA.
9
Georgetown University, Washington, DC, USA.
10
Mayo Clinic, Rochester, MN, USA.
11
Allan Blair Cancer Centre, Regina, SK, Canada.
12
The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
13
Seattle Cancer Care Alliance, Seattle, WA, USA.
14
Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA.
15
Roswell Park Cancer Institute, Buffalo, NY, USA. susan.mccann@roswellpark.org.
16
Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA. susan.mccann@roswellpark.org.

Abstract

BACKGROUND:

The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment.

METHODS:

Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group-Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10-30%, > 30%) (n = 900).

RESULTS:

The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66-0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01-1.40, p = 0.05).

CONCLUSIONS:

Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer.

TRIAL REGISTRATION:

ClinicalTrials.gov, NCT03413761 . Registered retrospectively on 29 January 2018.

KEYWORDS:

Breast cancer; Chemotherapy-induced peripheral neuropathy; Diet; Peripheral nervous system diseases; Taxane

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