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Foot Ankle Spec. 2018 Nov 28:1938640018815227. doi: 10.1177/1938640018815227. [Epub ahead of print]

The Role of Allograft Bone in Foot and Ankle Arthrodesis and High-Risk Fracture Management.

Hollawell S1,2,3, Kane B1,2,3, Heisey C1,2,3, Greenberg P1,2,3.

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Rutgers New Jersey Medical School, Newark, New Jersey (SH).
Jersey Shore University Medical Center; Neptune, New Jersey (BK, CH).
Jersey Shore University Medical Center, Hackensack-Meridian Research Department Neptune City, New Jersey (PG).


Allogenic bone graft has long been accepted as a standard of care in the surgical arthrodesis of the foot and ankle and treatment of certain high-risk, comminuted fracture types that have greater potential for delayed union or nonunion. It has been shown in multiple studies to be equivalent to autograft in regard to union rates without the morbidity associated with bone graft harvest. We present a retrospective study on the efficacy of an allogenic cancellous/periosteal cellular bone matrix with mesenchymal stem cells and angiogenic growth factors. The study includes a cohort of 41 procedures and 40 patients who underwent foot and ankle arthrodesis, fracture fixation, or a simultaneous combination of both. Radiographic consolidation of the fracture/fusion site was reviewed at regular intervals (first postoperative visit at 1 week and 4, 8, and 12 weeks and at regular intervals until healing was confirmed). Age, workmen's compensation insurance, diabetes, and nicotine use were evaluated as potential risk factors. Our retrospective study indicated that allograft bone has the potential to positively affect union rates in foot and ankle arthrodesis and certain high-risk fracture types that have potential for delayed union/nonunion. Levels of Evidence: Level IV.


allograft; arthrodesis; autograft; fracture; nonunion; revision


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