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Influenza Other Respir Viruses. 2019 Mar;13(2):208-212. doi: 10.1111/irv.12622. Epub 2018 Dec 17.

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia.

Author information

1
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
2
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
3
Department of Health Policy, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
4
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
5
Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
6
University of Western Australia, Perth, WA, Australia.
7
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
8
Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
9
Division of Hospital Medicine, Monroe Carell Jr. Children's Hospital, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
10
Division of Infectious Diseases, Monroe Carell Jr. Children's Hospital, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
11
Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Abstract

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

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