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PLoS One. 2018 Nov 28;13(11):e0207929. doi: 10.1371/journal.pone.0207929. eCollection 2018.

Obesity as an effect modifier of the association between menstrual abnormalities and hypertension in young adult women: Results from Project ELEFANT.

Author information

1
Department of Occupational & Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
2
Department of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China.
3
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China.
4
Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, United Kingdom.
5
Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
6
Tianjin Research Institute for Family Planning, Tianjin, China.
7
School of Materials Science and Engineering, Chang'an University, Xi'an, Shanxi, China.
8
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Abstract

BACKGROUND:

The menstrual cycle is regulated by reproductive hormones such as estrogen which has been implicated in the pathogenesis of hypertension and is associated with obesity. However, to date there has scant study of hypertension in relation to menstrual characteristics and abnormalities. We hypothesize that adverse menstrual characteristics are associated with an increase the prevalence of hypertension and that this relationship is exacerbated by obesity.

METHODS:

Our study leverages 178,205 healthy female participants (mean age = 29) in a population-based cross-sectional study in Tianjin, China. Menstrual characteristics including menstrual cycle length and regularity, menstrual bleeding length, menstrual blood loss and dysmenorrhea were assessed by self-reported questionnaires, and hypertension was diagnosed by physician. Multiple logistic regression models were used to assess the relationships between menstrual characteristics and hypertension.

RESULTS:

Normal length menstrual cycle (OR = 1.21, 95% CI: 1.03-1.41), oligomenorrhea (OR = 1.54, 95% CI: 1.12-2.07), irregular cycle (OR = 1.54, 95% CI: 1.22-1.93), and light menstrual blood loss (OR = 1.36, 95% CI: 1.06-1.72) were associated with hypertension among women who are overweight or obese, but not among women who are normal weight. Longer menstrual bleeding duration (OR = 1.44, 95% CI: 1.24-1.67) and dysmenorrhea were associated with increased prevalence of hypertension (OR = 1.20, 95% CI: 1.14-1.41) in all young women.

CONCLUSIONS:

The prevalence of hypertension is higher among women with menstrual abnormalities, and this association is modified by overweight and obesity.

PMID:
30485368
PMCID:
PMC6261602
DOI:
10.1371/journal.pone.0207929
[Indexed for MEDLINE]
Free PMC Article

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