Send to

Choose Destination
See comment in PubMed Commons below
Breast Cancer Res Treat. 1988 Jul;11(3):197-209.

The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole.

Author information

  • 1Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison 53792.


Tamoxifen, a nonsteroidal antiestrogen, is now the endocrine treatment most widely used in breast cancer, both in the adjuvant and advanced disease settings. Here we will trace the development of tamoxifen for advanced breast cancer in postmenopausal patients, consider the biological basis for the recent successful use of tamoxifen for long-term adjuvant therapy, and discuss the use of tamoxifen in premenopausal patients with advanced disease. In part, this will be a historical review offered as a tribute to the late Dr. Arthur L. Walpole, who must receive the chief credit for the discovery of tamoxifen and its subsequent application as an anticancer agent.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center