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Adv Exp Med Biol. 2018;1106:25-36. doi: 10.1007/978-3-030-00737-9_3.

Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease.

Author information

1
Institut de Recherches Cliniques de Montréal, QC, Canada.
2
Institut de Recherches Cliniques de Montréal, QC, Canada. benoit.coulombe@ircm.qc.ca.
3
Department of Biochemistry and Molecular Medicine, Université de Montréal, QC, Canada. benoit.coulombe@ircm.qc.ca.

Abstract

The PAQosome, formerly known as the R2TP/PFDL complex, is an eleven-subunit cochaperone complex that assists HSP90 in the assembly of numerous large multisubunit protein complexes involved in essential cellular functions such as protein synthesis, ribosome biogenesis, transcription, splicing, and others. In this review, we discuss possible mechanisms of action and role of phosphorylation in the assembly of client complexes by the PAQosome as well as its potential role in cancer, ciliogenesis and ciliopathies.

KEYWORDS:

Cancer; Chaperone; Ciliopathies; Cilium; Interactome; PAQosome; PDRG1; Phosphorylation; Prefoldin-like; Protein complex assembly; Protein network; Quaternary structure arrangement; R2TP; URI1; UXT

PMID:
30484151
DOI:
10.1007/978-3-030-00737-9_3
[Indexed for MEDLINE]

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