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Front Cell Dev Biol. 2018 Nov 12;6:150. doi: 10.3389/fcell.2018.00150. eCollection 2018.

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis.

Hou W1,2, Syn WK2,3.

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Tianjin Second People's Hospital and Tianjin Institute of Hepatology, Tianjin, China.
Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States.
Section of Gastroenterology, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, United States.


Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identified. This review specially focuses on the metabolic changes which impact on HSC activation and fibrogenesis.


fibroblast; glutaminolysis; glycolysis; liver fibrosis; metabolic

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