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Food Sci Biotechnol. 2018 Jul 13;27(6):1833-1842. doi: 10.1007/s10068-018-0431-0. eCollection 2018 Dec.

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome.

Author information

1
1Department of Public Health Science, Korea University, Seoul, 07249 Republic of Korea.
2
2Skin Biotechnology Center, Kyung Hee University, Yongin, Gyeonggi 16229 Republic of Korea.
3
3Department of Food Science and Technology, Seoul Women's University, Seoul, 01797 Republic of Korea.

Abstract

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

KEYWORDS:

GABA type A-benzodiazepine receptor; Glyceryl monolinoleate; Insomnia; Polygonatum sibiricum; Sleep

PMID:
30483448
PMCID:
PMC6233407
[Available on 2019-07-13]
DOI:
10.1007/s10068-018-0431-0

Conflict of interest statement

Compliance with ethical standardsThe authors declare no conflict of interest.

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