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Food Sci Biotechnol. 2018 Jul 13;27(6):1833-1842. doi: 10.1007/s10068-018-0431-0. eCollection 2018 Dec.

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome.

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1Department of Public Health Science, Korea University, Seoul, 07249 Republic of Korea.
2Skin Biotechnology Center, Kyung Hee University, Yongin, Gyeonggi 16229 Republic of Korea.
3Department of Food Science and Technology, Seoul Women's University, Seoul, 01797 Republic of Korea.


The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.


GABA type A-benzodiazepine receptor; Glyceryl monolinoleate; Insomnia; Polygonatum sibiricum; Sleep

[Available on 2019-07-13]

Conflict of interest statement

Compliance with ethical standardsThe authors declare no conflict of interest.

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