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Food Sci Biotechnol. 2018 May 29;27(6):1685-1689. doi: 10.1007/s10068-018-0403-4. eCollection 2018 Dec.

Migration study of caprolactam from polyamide 6 sheets into food simulants.

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1Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-701 Republic of Korea.
2Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea.
Nutrition Policy and Promotion Team, Korean Health Industry Development Institute, Osong, 363-951 Republic of Korea.
4Food Additives and Packaging Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, 28159 Republic of Korea.


Caprolactam, used in manufacturing polyamide (PA) 6, may threaten human health. Here, PA 6 sheets were produced by using a twin-screw extruder to evaluate its safety. Caprolactam migration concentrations from the PA 6 sheets into food simulants were evaluated according to the standard migration test conditions under the Korean Food Standards Codex (KFSC). Concentrations were investigated under various food simulants (distilled water, 4% acetic acid, 20 and 50% ethanol, and heptane) and storage conditions (at 25, 60, and 95 °C). Caprolactam migration concentrations into food simulants were determined as follows: 4% acetic acid (0.982 mg/L), distilled water (0.851 mg/L), 50% ethanol (0.624 mg/L), 20% ethanol (0.328 mg/L), and n-heptane (not detected). Migrations were determined to be under the regulatory concentration (15 mg/L) according to the KFSC test conditions. Taken together, these results verified that the standard migration test conditions by KFSC were reliable to evaluate the safety of PA 6.


Caprolactam; Food contact material; Korean Food Standards Codex regulation; Migration; Polyamide 6

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