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Front Neurol. 2018 Nov 12;9:952. doi: 10.3389/fneur.2018.00952. eCollection 2018.

High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study.

Zhou F1,2,3, Deng W1,2,3, Ding D4,5, Zhao Q4,5, Liang X4,5, Wang F1,2,3, Luo J1,2,3, Zheng L4,5, Guo Q4,5, Hong Z4,5.

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Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Key Lab of Health Technology Assessment, National Health and Family Planning Commission of the People's Republic of China (Fudan University), Shanghai, China.
Key Laboratory of Public Health Safety of Ministry of Education (Fudan University), Shanghai, China.
Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.


Background: The relationship between cholesterol and cognitive function is unclear from the previous studies. This study was conducted to explore this association in older Chinese adults. Methods: Data were from the Shanghai Aging Study, comprising 3,836 residents aged 50 years or over in an urban community. Diagnoses of dementia and mild cognitive impairment were established according to the fourth edition of diagnostic and statistical manual of mental disorders (DSM-IV) and Petersen criteria. Multivariate logistic regression models, non-matched and propensity score (PS) matched, were used to examine the association between cholesterol levels and cognitive function. Results: There was a significantly higher proportion of participants with low levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the dementia group than in groups without dementia (P < 0.05). High LDL-C level was inversely associated with dementia, with a negative trend in the PS matched model. TC and high density lipoprotein cholesterol (HDL-C) were not significantly related to dementia in either non-matched models or PS matched models. Conclusion: Our result indicates that high level of LDL-C is inversely associated with dementia. High level of LDL-C may be considered as a potential protective factor against cognition decline.


cognitive impairment; dementia; low density lipoprotein cholesterol; population-based study; propensity score matching

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