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Nat Cell Biol. 2018 Dec;20(12):1349-1360. doi: 10.1038/s41556-018-0236-7. Epub 2018 Nov 26.

Tumour heterogeneity and metastasis at single-cell resolution.

Author information

1
Department of Physiology and Biophysics, University of California, Irvine, CA, USA. dalawson@uci.edu.
2
Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. dalawson@uci.edu.
3
Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. kai.kessenbrock@uci.edu.
4
Department of Biological Chemistry, University of California, Irvine, CA, USA. kai.kessenbrock@uci.edu.
5
Department of Physiology and Biophysics, University of California, Irvine, CA, USA.
6
Department of Biological Chemistry, University of California, Irvine, CA, USA.
7
Center for Complex Biological Systems, University of California, Irvine, CA, USA.
8
Department of Anatomy, and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA, USA.

Abstract

Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications.

PMID:
30482943
DOI:
10.1038/s41556-018-0236-7
[Indexed for MEDLINE]

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