Format

Send to

Choose Destination
J Expo Sci Environ Epidemiol. 2019 Mar;29(2):172-182. doi: 10.1038/s41370-018-0096-z. Epub 2018 Nov 27.

Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013-2014 NHANES.

Author information

1
Rutgers School of Public, Department of Biostatistics and Epidemiology, Piscataway, NJ, USA. graber@eohsi.rutgers.edu.
2
Rutgers Environmental and Occupational Health Science Institute-Division of Exposure Science and Epidemiology, Piscataway, NJ, USA. graber@eohsi.rutgers.edu.
3
Rutgers School of Public, Department of Biostatistics and Epidemiology, Piscataway, NJ, USA.
4
Rutgers School of Public Health, Department of Environmental and Occupational Health, Piscataway, NJ, USA.
5
Rutgers Environmental and Occupational Health Science Institute-Clinical Research and Occupational Medicine, Piscataway, NJ, USA.
6
Rutgers Environmental and Occupational Health Science Institute-Division of Exposure Science and Epidemiology, Piscataway, NJ, USA.
7
Rutgers University Biostatistics and Epidemiology Services Center (RUBIES), Rutgers Biological and Health Sciences, Piscataway, NJ, USA.

Abstract

INTRODUCTION:

Per and polyfluoroalkyl substances (PFAS), including perfluorononanoic acid (PFNA) and perfluorooctanoic acid (PFOA), were detected in the community water supply of Paulsboro New Jersey in 2009.

METHODS:

A cross-sectional study enrolled 192 claimants from a class-action lawsuit, not affiliated with this study, who had been awarded a blood test for 13 PFAS. Study participants provided their blood test results and completed a survey about demographics; 105 participants also completed a health survey. Geometric means, 25th, 50th, 75th, and 95th percentiles of exposure of PFNA blood serum concentrations were compared to that of the 2013-2014 NHANES, adjusted for reporting level. Associations between PFNA, PFOA, PFOS, and PFHxS and self-reported health outcomes were assessed using logistic regression.

RESULTS:

PFNA serum levels were 285% higher in Paulsboro compared with U.S. residents. PFNA serum levels were higher among older compared with younger, and male compared to female, Paulsboro residents. After adjustment for potential confounding, there was a significant association between increased serum PFNA levels and self-reported high cholesterol (OR: 1.15, 95% CI: 1.02, 1.29).

DISCUSSION/CONCLUSION:

Further investigation into possible health effects of PFAS exposure in Paulsboro and other community settings is warranted. Since exposure has ceased, toxicokinetics of PFAS elimination should be explored.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center