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Euro Surveill. 2018 Nov;23(47). doi: 10.2807/1560-7917.ES.2018.23.47.1800617.

Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

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WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Swedish Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Clinical Microbiology, University of Dublin, Trinity College, St. James's Hospital, Dublin, Ireland.
Guide Clinic, St. James's Hospital, Dublin, Ireland.
APHP, St Louis Hospital, Laboratory of Microbiology; French National Reference Center for Bacterial STI, Associated laboratory for gonococci; Paris Diderot University, IAME, Sorbonne Paris Cité, Paris, France.
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
Authors contributed equally to the work and share joint authorship.
National Gonococcal Reference Laboratory, St. James's Hospital, Dublin, Ireland.


We describe a multidrug-resistant Neisseria gonorrhoeae urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating penA-60.001. Global awareness of spreading ceftriaxone-resistant gonococcal strains that threaten recommended dual therapies is essential.


FC428; Ireland; Neisseria gonorrhoeae; azithromycin; ceftriaxone; gonorrhoea; multidrug-resistant; resistance; treatment

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