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Dement Geriatr Cogn Disord. 2018 Nov 27;46(5-6):310-321. doi: 10.1159/000494348. [Epub ahead of print]

The Dépistage Cognitif de Québec: A New Clinician's Tool for Early Recognition of Atypical Dementia.

Author information

1
Clinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, CHU de Québec, Faculté de médecine, Université Laval, Québec, Québec, Canada.
2
CERVO Brain Research Centre, École de psychologie, Université Laval, Québec, Québec, Canada.
3
Département de Réadaptation, CERVO Brain Research Centre, Faculté de médecine, Université Laval, Québec, Québec, Canada.
4
Clinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, CHU de Québec, Faculté de médecine, Université Laval, Québec, Québec, Canadarobert.laforce@fmed.ulaval.ca.

Abstract

INTRODUCTION:

Early recognition of atypical dementia remains challenging partly because of lack of cognitive screening instruments precisely tailored for this purpose.

METHODS:

We assessed the validity and reliability of the Dépistage Cognitif de Québec (DCQ; www.dcqtest.org), a newly developed cognitive screening test, to detect atypical dementia using a multicenter cohort of 628 participants. Sensitivity and specificity were compared to the Montreal Cognitive Assessment (MoCA). A predictive diagnostic algorithm for atypical dementia was determined using classification tree analysis.

RESULTS:

The DCQ showed excellent psychometric properties. It was significantly more accurate than the MoCA to detect atypical dementia. All correlations between DCQ indexes and standard neuropsychological measures were significant. A statistical model distinguished typical from atypical dementia with a predictive power of 79%.

DISCUSSION:

The DCQ is a better tool to detect atypical dementia than standard cognitive screening tests. Expanding the clinician's tool kit with the DCQ could reduce missed/delayed identification of atypical dementia and accelerate therapeutic intervention.

KEYWORDS:

Alzheimer’s disease; Alzheimer’s variants; Atypical dementia; Cognitive assessment; Frontotemporal dementia; Frontotemporal lobar degeneration spectrum; Logopenic primary progressive aphasia; Neurocognitive disorders; Neurocognitive testing; Posterior cortical atrophy; Primary progressive aphasia; Screening tools

PMID:
30481754
DOI:
10.1159/000494348

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