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J Pestic Sci. 2018 Nov 20;43(4):266-271. doi: 10.1584/jpestics.D18-030.

Insecticidal properties of pyripyropene A, a microbial secondary metabolite, against agricultural pests.

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Agricultural & Veterinary Research Labs., Agricultural & Veterinary Division, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, 222-8567, Japan.
Graduate School of Infection Control Sciences, Kitasato Institute for life Sciences, Kitasato University, Tokyo, Japan.


We previously reported the strong insecticidal activity of a microbial secondary metabolite, pyripyropene A (PP-A), against aphids. Pyripyropenes (PPs) have been known to show weak feeding inhibition against lepidopteran pests, but their strong aphicidal activities were first reported in our former study. Here we investigated the details of the insecticidal property of PP-A. Our biological evaluation of PP-A found that it shows high insecticidal activities against some sucking pests, such as whiteflies, as well as aphids, and preferable biological profiles as agricultural insecticides. Furthermore, PP-A controlled aphids well under field conditions.


aphicide; hemiptera; natural product; pyripyropene

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