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Sci Rep. 2018 Nov 27;8(1):17409. doi: 10.1038/s41598-018-35663-2.

Radiopaque Fully Degradable Nanocomposites for Coronary Stents.

Author information

1
National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore, Singapore.
2
School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore, Singapore.
3
Department of Mechanical Engineering, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
4
Duke-NUS Medical School, 8 College Road, 169857, Singapore, Singapore.
5
School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore, Singapore. yingyinghuang@ntu.edu.sg.

Abstract

Bioresorbable scaffolds (BRS) were introduced to overcome limitations of current metallic drug-eluting stents and poly-L-lactide (PLLA) has been used in the fabrication of BRS due to its biodegradability and biocompatibility. However, such polymers have weaker mechanical properties as compared to metals, limiting their use in BRS. We hypothesized that nanofillers can be used to enhance the mechanical properties considerably in PLLA. To this end, polymer-matrix composites consisting of PLLA reinforced with 5-20 wt% barium sulfate (BaSO4) nanofillers as a potential BRS material was evaluated. Stearic-acid (SA) modified BaSO4 nanofillers were used to examine the effect of functionalization. Rigid nanofillers improved the tensile modulus and strength of PLLA (60% and 110% respectively), while the use of SA-BaSO4 caused a significant increase (~110%) in the elongation at break. Enhancement in mechanical properties is attributed to functionalization which decreased the agglomeration of the nanofillers and improved dispersion. The nanocomposites were also radiopaque. Finite element analysis (FEA) showed that scaffold fabricated from the novel nanocomposite material has improved scaffolding ability, specifically that the strut thickness could be decreased compared to the conventional PLLA scaffold. In conclusion, BaSO4/PLLA-based nanocomposites could potentially be used as materials for BRS with improved mechanical and radiopaque properties.

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