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Psychopharmacology (Berl). 2019 Apr;236(4):1159-1170. doi: 10.1007/s00213-018-5119-x. Epub 2018 Nov 26.

The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial.

Author information

1
Department of Psychology, Goldsmiths, University of London, 8 Lewisham Way, New Cross, London, SE14 6NW, UK.
2
Eleusis Pharmaceuticals Ltd, London, UK.
3
Centre for Psychiatry, Division of Brain Sciences, Imperial College London, London, UK.
4
Department of Psychology, Social Work, & Counselling, University of Greenwich, London, UK.
5
Department of Psychology, Goldsmiths, University of London, 8 Lewisham Way, New Cross, London, SE14 6NW, UK. d.terhune@gold.ac.uk.
6
Department of Experimental Psychology, University of Oxford, Oxford, UK. d.terhune@gold.ac.uk.

Abstract

RATIONALE:

Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness.

METHODS:

We conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 μg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals.

RESULTS:

LSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions.

CONCLUSIONS:

These results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.

KEYWORDS:

Interval timing; LSD; Microdosing; Older adults; Striatum

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