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Nat Methods. 2018 Dec;15(12):1021-1028. doi: 10.1038/s41592-018-0222-9. Epub 2018 Nov 26.

Acoustic tweezers for the life sciences.

Author information

1
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
2
Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA, USA.
3
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA. tony.huang@duke.edu.
4
Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA, USA. tony.huang@duke.edu.

Abstract

Acoustic tweezers are a versatile set of tools that use sound waves to manipulate bioparticles ranging from nanometer-sized extracellular vesicles to millimeter-sized multicellular organisms. Over the past several decades, the capabilities of acoustic tweezers have expanded from simplistic particle trapping to precise rotation and translation of cells and organisms in three dimensions. Recent advances have led to reconfigured acoustic tweezers that are capable of separating, enriching, and patterning bioparticles in complex solutions. Here, we review the history and fundamentals of acoustic-tweezer technology and summarize recent breakthroughs.

PMID:
30478321
PMCID:
PMC6314293
DOI:
10.1038/s41592-018-0222-9
[Indexed for MEDLINE]
Free PMC Article

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