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Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01628-18. doi: 10.1128/AAC.01628-18. Print 2019 Feb.

Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy.

Author information

1
National Reference Center for Invasive Mycoses, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
2
Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
3
Research Group PiDOMICs, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
4
Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
5
Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany.
6
Department of Medicine III: Medical Intensive Care, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
7
National Reference Center for Invasive Mycoses, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany okurzai@hygiene.uni-wuerzburg.de.
8
Institute for Hygiene and Microbiology, Julius Maximilian University of Wuerzburg, Wuerzburg, Germany.

Abstract

The opportunistic pathogen Candida glabrata shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart. Both isolates show pan-azole resistance and echinocandin resistance was acquired during the sampling interval. Genome sequencing identified nine nonsynonymous SNVs between the strains, including a S663P substitution in FKS2 and previously undescribed SNVs in MDE1 and FPR1, offering insight into how C. glabrata acquires drug resistance and adapts to a human host.

KEYWORDS:

Candida ; Candida glabrata ; candidiasis; comparative genomics; fungus; resistance

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