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Complement Ther Med. 2018 Dec;41:118-123. doi: 10.1016/j.ctim.2018.09.010. Epub 2018 Sep 17.

The effects of Zataria multiflora Boiss. (Shirazi thyme) on nonalcoholic fatty liver disease and insulin resistance: A randomized double-blind placebo-controlled clinical trial.

Author information

1
Research Center for Persian Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: shams@sums.ac.ir.
3
Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mnimruzi@yahoo.com.
4
Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
5
Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
6
Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
7
Gasteroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

OBJECTIVE:

The aim of the study is to evaluate the effects of Zataria multiflora Boiss. (Shirazi thyme) (ZM) supplementation on nonalcoholic fatty liver disease (NAFLD) and related insulin resistance (IR).

DESIGN:

In this randomized double-blind placebo-controlled clinical trial, 85 patients with NAFLD were administered either 700 mg ZM powder or placebo twice daily for 12 weeks. All patients were advised to follow the recommendations for diet modification.

RESULTS:

ZM supplementation resulted in a significant reduction in serum insulin level (-2.72 ± 0.80 vs -0.67 ± 0.90, P=0.030), insulin resistance (-0.80 ± 0.22 vs 0.06 ± 0.22, P=0.023), systolic (-3.44 ± 1.05 vs 1.03 ± 0.98, P= 0.002) and diastolic (-2.33 ± 0.77 vs 0.26 ± 0.63, P= 0.009) blood pressure in patients with NAFLD in comparison with the placebo group. There was no significant difference between two groups regarding serum levels of alanine aminotransferase (ALT), high sensitive C-reactive protein (hs-CRP), Tumor necrosis factor-α (TNF-α), grade of fatty liver in ultrasonography, lipid profiles, and other outcomes.

CONCLUSION:

ZM supplementation with daily dose of 1400 mg for 12 weeks improved insulin resistance in patients with NAFLD. Further studies with longer duration and larger sample size are recommended.

KEYWORDS:

Dietary supplements; Herbal medicine; Insulin resistance; Nonalcoholic fatty liver disease; Thymus plant; Traditional medicine; Zataria multiflora

Comment in

PMID:
30477827
DOI:
10.1016/j.ctim.2018.09.010
[Indexed for MEDLINE]

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