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Nutrients. 2018 Nov 25;10(12). pii: E1826. doi: 10.3390/nu10121826.

Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women.

Author information

1
Department of Geriatrics and Aging Research, University Hospital Zurich, 8091 Zurich, Switzerland. svea-vivica.mathieu@uzh.ch.
2
Centre on Aging and Mobility, University Hospital Zurich, 8091 Zurich, Switzerland. svea-vivica.mathieu@uzh.ch.
3
Department of Geriatrics and Aging Research, University Hospital Zurich, 8091 Zurich, Switzerland. karina.fischer@uzh.ch.
4
Centre on Aging and Mobility, University Hospital Zurich, 8091 Zurich, Switzerland. karina.fischer@uzh.ch.
5
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02153, USA. bess.dawson-hughes@tufts.edu.
6
Department of Geriatrics and Aging Research, University Hospital Zurich, 8091 Zurich, Switzerland. gregor.freystaetter@usz.ch.
7
Centre on Aging and Mobility, University Hospital Zurich, 8091 Zurich, Switzerland. gregor.freystaetter@usz.ch.
8
Department of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, 8091 Zurich, Switzerland. felix.beuschlein@usz.ch.
9
Department of Geriatrics and Aging Research, University Hospital Zurich, 8091 Zurich, Switzerland. simeon.schietzel@usz.ch.
10
Centre on Aging and Mobility, University Hospital Zurich, 8091 Zurich, Switzerland. simeon.schietzel@usz.ch.
11
Department of Geriatrics and Aging Research, University Hospital Zurich, 8091 Zurich, Switzerland. andreas.egli@usz.ch.
12
Centre on Aging and Mobility, University Hospital Zurich, 8091 Zurich, Switzerland. andreas.egli@usz.ch.
13
Department of Geriatrics and Aging Research, University Hospital Zurich, 8091 Zurich, Switzerland. heike.bischoff@usz.ch.
14
Centre on Aging and Mobility, University Hospital Zurich, 8091 Zurich, Switzerland. heike.bischoff@usz.ch.
15
University Clinic for Acute Geriatric Care, City Hospital Waid, 8037 Zurich, Switzerland. heike.bischoff@usz.ch.

Abstract

Obesity and sarcopenia are major causes of morbidity and mortality among seniors. Vitamin D deficiency is very common especially among seniors and has been associated with both muscle health and obesity. This study investigated if 25-hydroxyvitamin D (25(OH)D) status is associated with body composition and insulin resistance using baseline data of a completed RCT among relatively healthy community-dwelling seniors (271 seniors age 60+ years undergoing elective surgery for unilateral total knee replacement due to osteoarthritis). Cross-sectional analysis compared appendicular lean mass index (ALMI: lean mass kg/height m²) and fat mass index (FMI: fat mass kg/height m²) assessed by DXA and insulin resistance between quartiles of serum 25(OH)D concentration using multivariable linear regression adjusted for age, sex, smoking status, physical activity, and body mass index (BMI). Participants in the lowest serum 25(OH)D quartile (4.7⁻17.5 ng/mL) had a higher fat mass (9.3 kg/m²) compared with participants in the third (8.40 kg/m²; Q3 = 26.1⁻34.8 ng/mL) and highest (8.37 kg/m²; Q4 = 34.9⁻62.5 ng/mL) quartile (poverall = 0.03). Higher serum 25(OH)D quartile status was associated with higher insulin sensitivity (poverall = 0.03) and better beta cell function (p = 0.004). Prevalence of insulin resistance tended to be higher in the second compared with the highest serum 25(OH)D quartile (14.6% vs. 4.8%, p = 0.06). Our findings suggest that lower serum 25(OH)D status may be associated with greater fat mass and impaired glucose metabolism, independent of BMI and other risk factors for diabetes.

KEYWORDS:

ageing; body composition; diabetes; elderly; insulin resistance; metabolic syndrome; vitamin D

PMID:
30477276
PMCID:
PMC6315833
DOI:
10.3390/nu10121826
[Indexed for MEDLINE]
Free PMC Article

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