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Am J Clin Nutr. 2018 Nov 1;108(5):1113-1120. doi: 10.1093/ajcn/nqy198.

Coffee consumption and total mortality in a Mediterranean prospective cohort.

Author information

1
Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain.
2
Department of Cardiology, Complejo Hospitalario de Navarra, Servicio Navarro de Salud Osasunbidea, Pamplona, Spain.
3
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
4
Centro de Investigación Biomédica en Red Área de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Madrid, Spain.
5
Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA.
6
Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, Azienda Ospedaliera Policlinico-Universitaria "Vittorio Emanuele," Catania, Italy.
7
The Need for Nutrition Education/Innovation Programme (NNEdPro), University of Cambridge, Cambridge, United Kingdom.
8
Department of Preventive Medicine and Public Health & INCLIVA, Universidad de Valencia, Valencia, Spain.
9
Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
10
IdiPAZ (Instituto de Investigación Sanitaria Hospital Universitario La Paz), Madrid, Spain.
11
CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.

Abstract

Background:

The relation of coffee consumption with total mortality is controversial, because the available evidence is still inconsistent.

Objective:

This study aimed to assess this association in a highly educated, middle-aged Mediterranean cohort.

Design:

We analyzed data from 201,055 person-years of follow-up arising from 19,888 participants. Coffee consumption was obtained at baseline with the use of a previously validated semiquantitative food-frequency questionnaire. Information on mortality was ascertained by permanent contact with the "Seguimiento Universidad de Navarra" (SUN) participants and their families, postal authorities, and consultation of the National Death Index. We used Cox regression models to estimate HRs and 95% CIs for mortality according to baseline total coffee consumption adjusted for potential confounders. Sex, age, and baseline adherence to the Mediterranean diet were considered as potential effect modifiers.

Results:

Among the 19,888 participants, 337 died. Overall, in the multivariable adjusted analysis, we found a 22% lower risk of all-cause mortality for each 2 additional cups of total coffee per day (HR: 0.78; 95% CI: 0.66, 0.93). This association was stronger for participants aged ≥55 y (HR: 0.67; 95% CI: 0.52, 0.86) than for younger participants, who showed no significant association (P-interaction = 0.002).

Conclusion:

In a Mediterranean cohort, we found an inverse linear association between total coffee consumption and the risk of all-cause mortality that was strongest among participants older than 54 y.

PMID:
30475964
DOI:
10.1093/ajcn/nqy198

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