Format

Send to

Choose Destination
Mol Biotechnol. 2019 Feb;61(2):145-152. doi: 10.1007/s12033-018-0136-x.

Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways.

Author information

1
Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Derlakatte, Mangalore, Karnataka, 575018, India. boseshenoystemcell@gmail.com.
2
College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Kingdom of Saudi Arabia.
3
Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Derlakatte, Mangalore, Karnataka, 575018, India. shenoy@yenepoya.edu.in.

Abstract

The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.

KEYWORDS:

Cell signalling; Ocular stem cells; Oxidative damage; UVA; UVB; UVC

PMID:
30474787
DOI:
10.1007/s12033-018-0136-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center