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Elife. 2018 Nov 26;7. pii: e42849. doi: 10.7554/eLife.42849.

Ion channels and neuropathic pain.

Author information

1
Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Boston, United States.
2
Harvard Medical School, Harvard University, Boston, United States.
3
Department of Neurology, Massachusetts General Hospital, Boston, United States.
4
Department of Pathology, Massachusetts General Hospital, Boston, United States.

Abstract

Pain behaviors in a Fabry mouse model are associated with the accumulation of a fat molecule that disrupts sodium ion channels in small fiber neurons.

KEYWORDS:

Fabry disease; Gb3; mouse; neuropathy; small fibers; α-GAL

PMID:
30474609
PMCID:
PMC6255389
DOI:
10.7554/eLife.42849
[Indexed for MEDLINE]
Free PMC Article

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