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Curr Med Chem. 2018 Nov 25. doi: 10.2174/0929867326666181126113605. [Epub ahead of print]

Advances in carbon based nanomaterials for bio-medical applications.

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Amity Institute of Applied Sciences, Amity University, Sector-125, Noida 201313. India.
School of Mechanical Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar 752050. India.
Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beersheva. Israel.
Department of Aeronautical Engineering, Institute of Aeronautical Engineering, Dundigal, Hyderabad 500 043. India.
Multi-scale Analysis of Materials Research Unit, IMT School for Advanced Studies Lucca, Piazza San Francesco 19, 55100 Lucca. Italy.
Universit´e du Luxembourg, Maison du Nombre, 6, Avenue de la Fonte, L-4364 Esch-sur-Alzette. Luxembourg.


The unique mechanical, electrical, thermal, chemical and optical properties of carbon based nanomaterials (CBNs) like: Fullerenes, Graphene, Carbon nanotubes, and their derivatives made them widely used materials for various applications including biomedicine. Few recent applications of the CBNs in biomedicine include: cancer therapy, targeted drug delivery, bio-sensing, cell and tissue imaging and regenerative medicine. However, functionalization renders the toxicity of CBNs and makes them soluble in several solvents including water, which is required for biomedical applications. Hence, this review represents the complete study of development in nanomaterials of carbon for biomedical uses. Especially, CBNs as the vehicles for delivering the drug in carbon nanomaterials is described in particular. The computational modeling approaches of various CBNs are also addressed. Furthermore, prospectus, issues and possible challenges of this rapidly developing field are highlighted.


Biomedicine; Carbon based nanomaterials; Drug delivery; Functionalization; Toxicity.

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