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Int J Cancer. 2018 Nov 26. doi: 10.1002/ijc.32017. [Epub ahead of print]

The role of microbiota in the development of colorectal cancer.

Author information

1
Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
2
Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, China.
3
Department of Gastroenterology, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, China.

Abstract

Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation.

KEYWORDS:

carcinogenesis; colorectal cancer; inflammation; microbiota

PMID:
30474116
DOI:
10.1002/ijc.32017

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