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Biosci Rep. 2019 Jan 11;39(1). pii: BSR20181539. doi: 10.1042/BSR20181539. Print 2019 Jan 31.

Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice.

Author information

1
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine; No. 100 Cross Street, Hongshan Road, Nanjing 210028, China.
2
Center for Translational Systems Biology and Neuroscience and Key Laboratory of Integrative Biomedicine for Brain Diseases, College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
3
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China.
4
Brain Hospital Affiliated to Nanjing Medical University; No. 264, Guangzhou Road, Gulou District, Nanjing 210029, China.
5
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
6
The Second Affiliated Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine; No.23 Nanhu Road, Jianye District, Nanjing 210017, China.
7
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine; No. 100 Cross Street, Hongshan Road, Nanjing 210028, China hdn_2001@yahoo.com.
8
Center for Translational Systems Biology and Neuroscience and Key Laboratory of Integrative Biomedicine for Brain Diseases, College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China hdn_2001@yahoo.com.

Abstract

Conventional antidepressants have a disadvantage in delayed onset of efficacy. Here, we aimed to evaluate the immediate and persistent antidepressant-like action of a classic herbal medicine Chaihu-jia-Longgu-Muli decoction (CLM) as well as the action of CLM on hippocampal brain-derived neurotrophic factor (BDNF) over time. CLM consists of Xiaochaihu decoction (XchD), Longgu-Muli (LM) and several other herbs. The contribution of constituent herbal formula XchD and other parts of CLM was also assessed. Following a single dose of CLM, tail suspension test (TST), forced swim test (FST), and novelty-suppressed feeding test (NSF) were performed. The antidepressant activity of XchD, its interaction with LM or remaining parts of CLM was also examined after a single administration. BDNF expression in the hippocampus was examined at 30 min and 24 hr post a single CLM. A single administration of half of clinical dose of CLM elicited antidepressant effects at TST 30 min post administration, and lasted for 72 hr. Furthermore, CLM also reduced the latency to eat in NSF test. A single proportional dose of XchD induced antidepressant effects at 30 min and lasted for 48 hr, whereas the effect lasted for 72 hr when combined with either LM or the remaining parts of CLM. BDNF expression increased at 30 min and persisted at least for 24 hr after a single dose of CLM. The results support that Chaihu-jia-Longgu-Muli decoction was capable to immediately and enduringly elicit antidepressant activity via enhancement of hippocampal BDNF expression, in which the constituent Xiaochaihu decoction played the primary role.

KEYWORDS:

BDNF; Chaihu-jia-Longgu-Muli-tang; Immediate and persistent antidepressant-like effects; ketamine

PMID:
30473537
PMCID:
PMC6328878
DOI:
10.1042/BSR20181539
[Indexed for MEDLINE]
Free PMC Article

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